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Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of  Chlamydia trachomatis  antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer ( n  = 521) and population-based controls ( n  = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4–0.9). These data do not support our earlier finding of elevated titers for antibodies to  C. trachomatis  among women with ovarian cancer.

Chlamydia trachomatisSerology in Women with and without Ovarian Cancer