The Cold Contact Method as a Simple Drug Interaction Detection System | Zendy

Ilma Nugrahani | Zendy; Sukmadjaja Asyarie | Zendy; Sundani Nurono Soewandhi | Zendy; Slamet Ibrahim | Zendy

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The Cold Contact Method as a Simple Drug Interaction Detection System

Author(s) -

Ilma Nugrahani,

Sukmadjaja Asyarie,

Sundani Nurono Soewandhi,

Slamet Ibrahim

Publication year - 2008

Publication title -

research letters in physical chemistry

Language(s) - English

Resource type - Journals

eISSN - 1687-6881

pISSN - 1687-6873

DOI - 10.1155/2008/169247

Subject(s) - cocrystal , crystallization , melting point , materials science , solid state , chemistry , organic chemistry , molecule , composite material , hydrogen bond

The physical interaction between 2 substances frequently occurs along the mixing and manufacturing of solid drug dosage forms. The physical interaction is generally based on coarrangement of crystal lattice of drug combination. The cold contact method has been developed as a simple technique to detect physical interaction between 2 drugs. This method is performed by observing new habits of cocrystal that appear on contact area of crystallization by polarization microscope and characterize this cocrystal behavior by melting point determination. Has been evaluated by DSC, this method is proved suitable to identify eutecticum interaction of pseudoephedrine HCl-acetaminophen, peritecticum interaction of methampyrone-phenylbutazon, and solid solution interaction of amoxicillin-clavulanate, respectively.

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