Effect of different agents onto multidrug resistant tumor cells revealed by fluorescence correlation spectroscopy | Zendy

Céline Boutin | Zendy; Yann Roche | Zendy; Christine Millot | Zendy; Régis Deturche | Zendy; Jérôme Plain | Zendy; Pierre Jeannesson | Zendy; Michel Manfait | Zendy; Pascal Royer | Zendy; JeanMarc Millot | Zendy; Rodolphe Jaffiol | Zendy

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Effect of different agents onto multidrug resistant tumor cells revealed by fluorescence correlation spectroscopy

Author(s) -

Céline Boutin,

Yann Roche,

Christine Millot,

Régis Deturche,

Jérôme Plain,

Pierre Jeannesson,

Michel Manfait,

Pascal Royer,

JeanMarc Millot,

Rodolphe Jaffiol

Publication year - 2008

Publication title -

spectroscopy an international journal

Language(s) - English

Resource type - Journals

eISSN - 1875-922X

pISSN - 0712-4813

DOI - 10.1155/2008/153179

Subject(s) - membrane fluidity , membrane , verapamil , fluorescence correlation spectroscopy , chemistry , fluorescence , biophysics , fluorescence spectroscopy , cell membrane , multiple drug resistance , cell , diffusion , fluorescence anisotropy , biochemistry , biology , molecule , organic chemistry , calcium , antibiotics , physics , thermodynamics , quantum mechanics

Fluorescence correlation spectroscopy (FCS) has been used to analyze the plasma membrane fluidity and heterogeneity of multidrug resistant cells. At the single cell level, the effects of different membrane agents present in the extra-cellular medium have been explored. Firstly, we reveal a modification of plasma membrane heterogeneities according to the addition of a fluidity modulator, benzyl alcohol. On the other hand, revertants such as verapamil and cyclosporin-A appear to act more specifically on the slow diffusion sites, such as lipids microdomains.

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