Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas | Zendy

Arjen H.G. Cleven | Zendy; Ma van Engeland | Zendy; Bradly G. Wouters | Zendy; Adriaan P. de Bruı̈ne | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas

Author(s) -

Arjen H.G. Cleven,

Ma van Engeland,

Bradly G. Wouters,

Adriaan P. de Bruı̈ne

Publication year - 2007

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2007/945802

Subject(s) - stromal cell , tumor hypoxia , colorectal cancer , hypoxia (environmental) , immunohistochemistry , glut1 , cancer research , stroma , tumor progression , biology , pathology , tumor microenvironment , hypoxia inducible factors , medicine , oncology , radiation therapy , glucose transporter , cancer , tumor cells , chemistry , gene , biochemistry , organic chemistry , oxygen , insulin

Hypoxia modifies the phenotype of tumors in a way that promotes tumor aggressiveness and resistance towards chemotherapy and radiotherapy. However, the expression and influence of hypoxia-regulated proteins on tumor biology are not well characterized in colorectal tumors. We studied the role of protein expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1) in patients with colorectal adenocarcinomas.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research