DNA-Metallodrugs Interactions Signaled by Electrochemical Biosensors: An Overview | Zendy

Mauro Ravera | Zendy; Graziana Bagni | Zendy; Marco Mascini | Zendy; Domenico Osella | Zendy

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DNA-Metallodrugs Interactions Signaled by Electrochemical Biosensors: An Overview

Author(s) -

Mauro Ravera,

Graziana Bagni,

Marco Mascini,

Domenico Osella

Publication year - 2007

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2007/91078

Subject(s) - biosensor , guanine , dna , nucleobase , context (archaeology) , chemistry , intercalation (chemistry) , nanotechnology , combinatorial chemistry , electrochemistry , biophysics , biochemistry , electrode , materials science , inorganic chemistry , biology , nucleotide , paleontology , gene

The interaction of drugs with DNA is an important aspect in pharmacology. In recent years, many important technological advances have been made to develop new techniques to monitor biorecognition and biointeraction on solid devices. The interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases. The propensity of a given compound to interact with DNA is measured as a function of the decrease of guanine oxidation signal on a DNA electrochemical biosensor. Covalent binding at N7 of guanine, electrostatic interactions, and intercalation are the events that this kind of biosensor can detect. In this context, the interaction between a panel of antitumoral Pt-, Ru-, and Ti-based metallodrugs with DNA immobilized on screen-printed electrodes has been studied. The DNA biosensors are used for semiquantitative evaluation of the analogous interaction occurring in the biological environment.

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