Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C | Zendy

Robert P. Myers | Zendy; Djamila Messous | Zendy; Thierry Poynard | Zendy; Françoise ImbertBismut | Zendy

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Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C

Author(s) -

Robert P. Myers,

Djamila Messous,

Thierry Poynard,

Françoise ImbertBismut

Publication year - 2007

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2007/876076

Subject(s) - leptin , steatosis , medicine , body mass index , gastroenterology , fibrosis , fatty liver , receiver operating characteristic , endocrinology , histology , hepatitis c , hepatitis c virus , obesity , immunology , virus , disease

Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the present study was to determine the clinical and histological correlates of serum leptin in HCV-infected patients, and to determine its utility in predicting liver histological lesions.

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