Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione | Zendy

D. Giles | Zendy; Muthuramalingam Prakash | Zendy; K. V. Ramseshu | Zendy

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Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione

Author(s) -

D. Giles,

Muthuramalingam Prakash,

K. V. Ramseshu

Publication year - 2007

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2007/865470

Subject(s) - chemistry , sodium ethoxide , indane , organic chemistry , thio , antifungal , phthalate , medicinal chemistry , derivative (finance) , sodium salt , medicine , dermatology , ethanol , financial economics , economics , inorganic chemistry

Indane-1, 3-dione (1) synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide (3) which on treatment with 1 gave 2-substituted thio phenyl derivatives (4a-g) of 1. The synthesized compounds were characterized on the basis of I.R and H1NMR. Synthesized compounds (4a-g) were investigated for their anticoagulant, analgesic, anti-inflammatory, antifungal, antibacterial and anticancer activities. Some of the synthesized compounds have shown moderate activities

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