Intratumor Genetic Heterogeneity of Breast Carcinomas as Determined by Fine Needle Aspiration and TaqMan Low Density Array | Zendy

Maria Lyng | Zendy; AnneVibeke Lænkholm | Zendy; Niels Pallisgaard | Zendy; Werner Vach | Zendy; Ann Knoop | Zendy; Martin Bak | Zendy; Henrik J. Ditzel | Zendy

Open Access

Intratumor Genetic Heterogeneity of Breast Carcinomas as Determined by Fine Needle Aspiration and TaqMan Low Density Array

Author(s) -

Maria Lyng,

AnneVibeke Lænkholm,

Niels Pallisgaard,

Werner Vach,

Ann Knoop,

Martin Bak,

Henrik J. Ditzel

Publication year - 2007

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2007/860194

Subject(s) - fine needle aspiration , taqman , breast cancer , medicine , genetic heterogeneity , cancer research , pathology , biology , computational biology , polymerase chain reaction , cancer , genetics , gene , biopsy , phenotype

Gene expression profiling is thought to be an important tool in determining treatment strategies for breast cancer patients. Tissues for such analysis may at a preoperative stage be obtained, by fine needle aspiration (FNA) allowing initiation of neoadjuvant treatment. To evaluate the extent of the genetic heterogeneity within primary breast carcinomas, we examined whether a gene expression profile obtained by FNA was representative of the tumor.

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