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We report a methodology for labeling the GABAc receptor on the surface membrane of intact cells. This work builds upon our earlier work with serotonin-conjugated quantum dots and our studies with PEGylated quantum dots to reduce nonspecific binding. In the current approach, a PEGylated derivative of muscimol was synthesized and attached via an amide linkage to quantum dots coated in an amphiphilic polymer derivative of a modified polyacrylamide. These conjugates were used to image GABAC receptors heterologously expressed in Xenopus laevis  oocytes

journal of biomedicine and biotechnology

Imaging<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>GABA</mml:mtext></mml:mrow><mml:mtext>c</mml:mtext></mml:msub></mml:mrow></mml:math>Receptors with Ligand-Conjugated Quantum Dots

ImagingGABAcReceptors with Ligand-Conjugated Quantum Dots