English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Three novel stable Pt(III) complexes with distorted octahedral structure and(   d    z  2)   1ground state have been obtained in the course of Pt(II)-hematoporphyrin IX ((7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H-23H-porphyn-2,18-dipropionic acid), Hp) interaction in alkaline aqueous medium and aerobic conditions.  A redox interaction also takes place together with the complexation process leading to the formation of Pt(III) species and organic radicals. The processes in the reaction system and the structure of the complexes formed  cis -[Pt(III)(NH   3    )    2(Hp    −  3  H)(    H  2   O   )    2]   ⋅    H  2   O1 , [Pt(III)(Hp    −  3  H)(    H  2   O   )    2]   ⋅    H  2   O2 , and [Pt((O,O)Hp    −  2  H)Cl(    H  2   O   )    3]  3 , were studied by UV-Vis, IR, EPR and XPS spectra, thermal (TGS, DSC), potentiometric and magnetic methods. The newly synthesized complexes show promising cytotoxic activity comparable with that of   cis -platin in in vitro tests against a panel of human leukemia cell lines. The observed cytotoxicity of the complex  2  against SKW-3 cells (KE-37 derivative) is due to induction of cell death through apoptosis.

Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents