Angiogenic Factor Expression in Hepatic Cirrhosis | Zendy

Alexandra Giatromanolaki | Zendy; Stamatia Kotsiou | Zendy; Michael I. Koukourakis | Zendy; Efthimios Sivridis | Zendy

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Angiogenic Factor Expression in Hepatic Cirrhosis

Author(s) -

Alexandra Giatromanolaki,

Stamatia Kotsiou,

Michael I. Koukourakis,

Efthimios Sivridis

Publication year - 2007

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2007/67187

Subject(s) - cirrhosis , basic fibroblast growth factor , hepatic fibrosis , angiogenesis , thymidine phosphorylase , vascular endothelial growth factor , fibrosis , pathogenesis , hepatic stellate cell , growth factor , immunohistochemistry , cancer research , biology , fibroblast growth factor , pathology , fibroblast , medicine , endocrinology , vegf receptors , cell culture , cancer , receptor , genetics

The pathogenesis of fibrosis in hepatic cirrhosis remains obscure. This study examines the eventual role of angiogenic factors in the fibrotic process. A series of 55 cirrhotic livers was studied for the proliferation state of fibroblasts, and the expression of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and the basic and acidic fibroblast growth factor (bFGF, aFGF) in both fibroblasts and hepatic cells. The angiogenic and/or fibrogenic factors VEGF, TP, bFGF, and aFGF were clearly expressed in regenerative hepatocytes, but not in fibroblasts of diffuse hepatic fibrosis. The immunohistochemical findings suggest that angiogenic factors and factors promoting oxidative stress (i.e., TP) produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis.

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