Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes | Zendy

Basavaraju Bennehalli | Zendy; H. S. Bhojya Naik | Zendy; M.C. Prabhakara | Zendy

Open Access

Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes

Author(s) -

Basavaraju Bennehalli,

H. S. Bhojya Naik,

M.C. Prabhakara

Publication year - 2006

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2007/639828

Subject(s) - antimicrobial , metal , chemistry , elemental analysis , nuclear chemistry , antifungal , potassium , chelation , antibacterial activity , ligand (biochemistry) , characterization (materials science) , iodide , iodine , stereochemistry , combinatorial chemistry , bacteria , nanotechnology , inorganic chemistry , organic chemistry , microbiology and biotechnology , materials science , biochemistry , biology , genetics , receptor

2-Chloro-6-methylquinoline-3-carbaldehyde was condensed with o-Phenylenediammine and 2-aminophenol in presence of potassium iodide. The resulting Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methylquinolino[3,2-b][1,5]benzoxazepine(MQBO) were characterized by elemental analysis and spectral studies. The metal chelates viz Pd(II), Rh(III) and Ru(III) of ligands were prepared and characterized by metal-ligand (M:L) ratio, UV-Visible, IR, 1H NMR spectroscopes and magnetic properties. The antibacterial and antifungal activity of MQBD, MQBO and its metal complexes were screened against various bacteria and fungi. The results show that all these samples are good antimicrobial agents.

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