Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation | Zendy

Eimear Mullen | Zendy; Peili Gu | Zendy; Austin J. Cooney | Zendy

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Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation

Author(s) -

Eimear Mullen,

Peili Gu,

Austin J. Cooney

Publication year - 2007

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2007/61563

Subject(s) - sox2 , nuclear receptor , homeobox protein nanog , induced pluripotent stem cell , embryonic stem cell , microbiology and biotechnology , cellular differentiation , biology , transcription factor , phenotype , receptor , cell , genetics , gene

Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose the human body. The switch from the pluripotent phenotype to a differentiated cell involves many complex signaling pathways including those involving LIF/Stat3 and the transcription factors Sox2, Nanog and Oct-4. Many nuclear receptors play an important role in the maintenance of pluripotence (ERR β , SF-1, LRH-1, DAX-1) repression of the ES cell phenotype (RAR, RXR, GCNF) and also the differentiation of ES cells (PPAR γ ). Here we review the roles of the nuclear receptors involved in regulating these important processes in ES cells.

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