Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged  | Zendy

Emiel A. M. Janssen | Zendy; Håvard Søiland | Zendy; Ivar Skaland | Zendy; Einar Gudlaugson | Zendy; Kjell H. Kjellevold | Zendy; Arne Nysted | Zendy; Jon-Arne Søreide | Zendy; Jan P. A. Baak | Zendy

Open Access

Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged <55 years

Author(s) -

Emiel A. M. Janssen,

Håvard Søiland,

Ivar Skaland,

Einar Gudlaugson,

Kjell H. Kjellevold,

Arne Nysted,

Jon-Arne Søreide,

Jan P. A. Baak

Publication year - 2007

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2007/569246

Subject(s) - pten , medicine , breast cancer , pi3k/akt/mtor pathway , oncology , protein kinase b , chemotherapy , cancer , mitotic index , cancer research , biology , mitosis , signal transduction , biochemistry , microbiology and biotechnology

The prognostic value of the PI3K/Akt/mTOR pathway and PTEN in invasive breast cancer (IBC) is controversial. Cell proliferation, especially the Mitotic Activity Index (MAI), is strongly prognostic in lymph node-negative (LNneg) invasive breast cancer. However, its prognostic value has not been compared with the value of Akt and PTEN expression.

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