Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas | Zendy

Dianne M. Heijink | Zendy; J H Kleibeuker | Zendy; Mathilde Jalving | Zendy; W. Boersma-van Ekb | Zendy; Jan J. Koornstra | Zendy; Jelle Wesseling | Zendy; Steven de Jong | Zendy

Open Access

Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas

Author(s) -

Dianne M. Heijink,

J H Kleibeuker,

Mathilde Jalving,

W. Boersma-van Ekb,

Jan J. Koornstra,

Jelle Wesseling,

Steven de Jong

Publication year - 2007

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2007/564605

Subject(s) - downregulation and upregulation , colorectal cancer , immunohistochemistry , cancer research , carcinogenesis , apoptosis , medicine , caspase 3 , pathology , biology , cancer , programmed cell death , gene , biochemistry

TNF-Related Apoptosis Inducing Ligand (TRAIL) is a promising agent for the induction of apoptosis in neoplastic tissues. Important determinants of TRAIL sensitivity are two intracellular proteins of the TRAIL pathway, caspase-8 and its anti-apoptotic competitor cellular Flice-Like Inhibitory Protein (cFLIP).

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