Open AccessCD31 and CD34 Expression as Immunohistochemical Markers of Endothelial Transdifferentiation in Human Cutaneous Melanoma
Author(s) -
Alberto Pisacane,
Franco Picciotto,
Mauro Risio
Publication year - 2007
Publication title -
analytical cellular pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 24
eISSN - 2210-7185
pISSN - 2210-7177
DOI - 10.1155/2007/486579
Subject(s) - cd31 , immunohistochemistry , cd34 , pathology , transdifferentiation , biology , cancer research , medicine , stem cell , microbiology and biotechnology
Vasculogenic mimicry, as previously described in aggressive melanoma, is characterized by the de novo generation of intratumoral patterned vascular channels, composed of PAS-positive basement membrane in the absence of endothelial cells, providing additional microcirculation, in support to the classic tumoral angiogenesis.
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