English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Urogenital infections of bacterial origin have a high incidence among the world female population at reproductive age. Lactobacilli, the predominant microorganisms of the healthy vaginal microbiota, have shown a protective effect against the colonization and overgrowth of urogenital pathogens that increased the interest for including them into probiotics products assigned to restore the urogenital balance. In the present work, we determined in a mouse animal model the capability of  Lactobacillus paracasei   CRL 1289, a human vaginal strain with probiotic properties, to prevent the vaginal colonization of a uropathogenic strain of  Staphylococcus aureus . Six-week-old female BALB/c mice, synchronized in their estral cycle, were intravaginally inoculated with two doses of 10 9  lactobacilli before challenging them with a single dose of 10 5  or 10 7  CFU of  S. aureus . The vaginal colonization of both microorganisms and the effect on the vaginal structure were determined at 2, 5, and 7 days after pathogen inoculation. Control mice and those challenged only with the pathogen showed an insignificant lactobacilli population, whereas 10 5  lactobacilli/mL of vaginal homogenate were recovered at 2 days after challenge from the  L. paracasei  CRL 1289 and the probiotic + pathogen groups, decreasing this number on the following days. The treatment with  L. paracasei  CRL 1289 decreased significantly the number of staphylococci recovered at 2 and 5 days when mice were challenged only with 10 5  CFU of pathogen. The inoculation of  S. aureus  produced a remarkable inflammatory response and structural alterations in the vaginal mucosa that decreases in a significant manner when the mice were protected with  L. paracasei  CRL 1289. The results obtained suggest that this particular  Lactobacillus  strain could prevent the onset of urogenital infections by interfering with the epithelial colonization by uropathogenic  S. aureus .

infectious diseases in obstetrics and gynecology

Protective Effect of Vaginal<i>Lactobacillus paracasei</i>CRL 1289 against Urogenital Infection Produced by<i>Staphylococcus aureus</i>in a Mouse Animal Model

Protective Effect of VaginalLactobacillus paracaseiCRL 1289 against Urogenital Infection Produced byStaphylococcus aureusin a Mouse Animal Model