Open AccessProinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease
Author(s) -
Ivan Borges,
Emília Addison Machado Moreira,
Danilo Wilhem Filho,
Tiago Bittencourt de Oliveira,
Marcelo Barreto Spirelle da Silva,
Tânia Sílvia Fröde
Publication year - 2007
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/2007/45794
Subject(s) - oxidative stress , glutathione peroxidase , tbars , glutathione , chemistry , glutathione reductase , biochemistry , catalase , lipid peroxidation , enzyme
Objective . To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods . Eighteen subjects were divided in two groups: experimental (age52.9 ± 5.0 ) and control (age51.1 ± 9.6 ). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Studentttest andP < .05 . Results . Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group ( P < .05 ). Conclusion . The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
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