Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation | Zendy

Ana Roussoulières | Zendy; Brigitte McGregor | Zendy; Lara Chalabreysse | Zendy; Catherine Cerutti | Zendy; JeanneLuce Garnier | Zendy; P. Boissonnat | Zendy; Olivier Bastien | Zendy; JeanYves Scoazec | Zendy; Françoise Thivolet-Béjui | Zendy; Laurent Sebbag | Zendy; John L. McGregor | Zendy

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Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation

Author(s) -

Ana Roussoulières,

Brigitte McGregor,

Lara Chalabreysse,

Catherine Cerutti,

JeanneLuce Garnier,

P. Boissonnat,

Olivier Bastien,

JeanYves Scoazec,

Françoise Thivolet-Béjui,

Laurent Sebbag,

John L. McGregor

Publication year - 2007

Publication title -

journal of biomedicine and biotechnology

Language(s) - English

Resource type - Journals

eISSN - 1110-7251

pISSN - 1110-7243

DOI - 10.1155/2007/41705

Subject(s) - transplantation , ve cadherin , cd34 , peritubular capillaries , immunohistochemistry , staining , pathology , cadherin , kidney , kidney transplantation , human kidney , endothelium , biology , andrology , medicine , cell , endocrinology , stem cell , microbiology and biotechnology , genetics

Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human hearttransplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining byimmunohistochemistry (no AR (n=5), AR grade IA (n=5), or AR grade IIA (n=5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P=.01) and to AR grade IA (P=.02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR

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