Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis

Aim . To determine serum IL-1 β , IL-6, IL-8, and TNF- αlevels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods . This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis ( n = 12 ), as culture-negative sepsis ( n = 21 ), and as healthy newborns ( n = 17 ). Results . At the time of diagnosis, serum IL-1 β , IL-6, IL-8, and TNF- αlevels of culture-proven sepsis were significantly higher than those of the control groups ( P < .05 ). At the time of diagnosis, IL-1 β , IL-6, IL-8, and TNF- αlevels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion . Serum IL-1 β , IL-6, IL-8, and TNF- αare mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.