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Aim . To determine serum IL-1    β    , IL-6, IL-8, and TNF-    αlevels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up.  Methods . This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (    n  =  12    ), as culture-negative sepsis (    n  =  21    ), and as healthy newborns (    n  =  17    ).  Results . At the time of diagnosis, serum IL-1    β    , IL-6, IL-8, and TNF-    αlevels of culture-proven sepsis were significantly higher than those of the control groups (    P  <  .05    ). At the time of diagnosis, IL-1    β    , IL-6, IL-8, and TNF-    αlevels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment.  Conclusion . Serum IL-1    β    , IL-6, IL-8, and TNF-    αare mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.

Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis