RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury | Zendy

Sabien van Neerven | Zendy; Jörg Mey | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury

Author(s) -

Sabien van Neerven,

Jörg Mey

Publication year - 2007

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2007/29275

Subject(s) - retinoid x receptor , retinoid , peroxisome proliferator activated receptor , transcription factor , receptor , spinal cord , signal transduction , microbiology and biotechnology , neuroscience , biology , nuclear receptor , medicine , retinoic acid , biochemistry , gene

The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experiments show how RAR signaling may improve axonal regeneration and modulate reactions of glia cells. While anti-inflammatory properties of PPAR are well documented in the periphery, their possible roles in the central nervous system have only recently become evident. Due to its anti-inflammatory function this transcription factor family promises to be a useful target after spinal cord or brain lesions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research