On the prenylation of some indolic and imidazolic bases by oxirane auxiliaries under thermal and microwave conditions | Zendy

Christopher K. Jankowski | Zendy; Étienne Dako | Zendy; Antoun Bou Laouz | Zendy; Marcel Delaforge | Zendy; Jocelyn R. Parè | Zendy; Jacqueline M.R. Bélanger | Zendy

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On the prenylation of some indolic and imidazolic bases by oxirane auxiliaries under thermal and microwave conditions

Author(s) -

Christopher K. Jankowski,

Étienne Dako,

Antoun Bou Laouz,

Marcel Delaforge,

Jocelyn R. Parè,

Jacqueline M.R. Bélanger

Publication year - 2007

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2007/153149

Subject(s) - isoprene , chemistry , prenylation , nucleophile , epoxide , organic chemistry , ring (chemistry) , stereochemistry , combinatorial chemistry , polymer , enzyme , catalysis , copolymer

The analogue of isoprene, 2-methyl-2-vinyloxirane, a versatile isoprene auxiliary, was reacted with some indolic and imidazolic bases, to add one or more isoprene unit(s), to these compounds. This prenylation was realised by using thermal and microwave assisted pathways, via the nucleophilic opening of the epoxide ring. The biological importance of the prenylated derivatives resides in their potential application as drugs. The aminoacids and small protein biomarkers are obtained from simple epoxide opening reactions. All new compounds were characterised by high resolution NMR, mass spectroscopy, GC-MS and LC-MS as well.

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