Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2 | Zendy

A. Alfaro | Zendy; Minh Tuan Doan | Zendy; John M. Finke | Zendy; M. Galdes | Zendy; Mohamed Zohdy | Zendy

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Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2

Author(s) -

A. Alfaro,

Minh Tuan Doan,

John M. Finke,

M. Galdes,

Mohamed Zohdy

Publication year - 2006

Publication title -

applied bionics and biomechanics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.397

H-Index - 23

eISSN - 1754-2103

pISSN - 1176-2322

DOI - 10.1155/2006/841046

Subject(s) - divide and conquer algorithms , chymotrypsin , protein tertiary structure , computational biology , computer science , amyotrophic lateral sclerosis , algorithm , dimension (graph theory) , theoretical computer science , bioinformatics , chemistry , biology , biochemistry , mathematics , disease , combinatorics , enzyme , medicine , trypsin , pathology

Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2.

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