RP‐HPLC Determination of Raloxifene in Pharmaceuticl Tablets | Zendy

P. Venkata Reddy | Zendy; B. Sudha Rani | Zendy; G. Srinu Babu | Zendy; J. V. L. N. Seshagiri Rao | Zendy

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RP‐HPLC Determination of Raloxifene in Pharmaceuticl Tablets

Author(s) -

P. Venkata Reddy,

B. Sudha Rani,

G. Srinu Babu,

J. V. L. N. Seshagiri Rao

Publication year - 2006

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2006/713569

Subject(s) - chemistry , chromatography , raloxifene , high performance liquid chromatography , acetonitrile , phosphate buffered saline , dosage form , retention time , linear range , detection limit , breast cancer , medicine , cancer , estrogen receptor

A reverse phase HPLC method is developed for the determination of Raloxifene in pharmaceutical dosage forms. Chromatography was carried out on an inertsil C18 column using a mixture of acetonitrile and phosphate buffer (30:70 v/v) as the mobile phase at a flow rate of 1 mL/min. Detection was carried out at 290 nm .The retention time of the drug was 10.609 min. The method produced linear responses in the concentration range of 0.5-200 µg/mL of Raloxifene. The method was found to be applicable for determination of the drug in tablets.

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