Synthetic studies of Alkoxy isoindole‐1,3‐diones tetra‐azabenzo[f]azulenes and their Antibacterial activity | Zendy

M. Giasuddin Ahmed | Zendy; Richa Sharma | Zendy; Devendra Prakash Nagda | Zendy; Vijay Kumar Salvi | Zendy; G. L. Talesara | Zendy

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Synthetic studies of Alkoxy isoindole‐1,3‐diones tetra‐azabenzo[f]azulenes and their Antibacterial activity

Author(s) -

M. Giasuddin Ahmed,

Richa Sharma,

Devendra Prakash Nagda,

Vijay Kumar Salvi,

G. L. Talesara

Publication year - 2006

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2006/679374

Subject(s) - chemistry , isoindole , anhydrous , alkoxy group , medicinal chemistry , tetra , condensation , antibacterial activity , sodium salt , organic chemistry , stereochemistry , bacteria , inorganic chemistry , alkyl , physics , thermodynamics , genetics , biology

3-Methylpyrazol-5-one 3 reacts with substituted benzaldehydes 4a-d in the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones 5a-d and the condensation of 5a-d with 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones 2a-c furnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones 6a-l, which on cyclisation with o-phenylendiamine give titled compounds 7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties

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