Cytokeratin Profiles Identify Diagnostic Signatures in Colorectal Cancer Using Multiplex Analysis of Tissue Microarrays | Zendy

Thomas Knösel | Zendy; Valeska Emde | Zendy; Karsten Schlüns | Zendy; Peter M. Schlag | Zendy; Manfred Dietel | Zendy; Iver Petersen | Zendy

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Cytokeratin Profiles Identify Diagnostic Signatures in Colorectal Cancer Using Multiplex Analysis of Tissue Microarrays

Author(s) -

Thomas Knösel,

Valeska Emde,

Karsten Schlüns,

Peter M. Schlag,

Manfred Dietel,

Iver Petersen

Publication year - 2006

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2006/354295

Subject(s) - cytokeratin , tissue microarray , multiplex , colorectal cancer , dna microarray , pathology , computational biology , cancer , biology , medicine , immunohistochemistry , bioinformatics , genetics , gene expression , gene

Recent cDNA expression profiling analyses indicate that within specific organ cancers Cytokeratins (CKs) dysregulation may identify subgroups with distinct biological phenotypes. Our objectives in this study were (1) to test whether cytokeratins were also distinct on the protein level, (2) to evaluate these biomarkers in a series of well-characterised CRCs, (3) to apply hierarchical cluster analysis to immunohistochemical data.

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