Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC | Zendy

B. Sudha Rani | Zendy; P. Venkata Reddy | Zendy

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Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC

Author(s) -

B. Sudha Rani,

P. Venkata Reddy

Publication year - 2006

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2006/252570

Subject(s) - chromatography , ziprasidone , chemistry , high performance liquid chromatography , methanol , dosage form , phosphate buffered saline , phase (matter) , organic chemistry , schizophrenia (object oriented programming) , clozapine , computer science , programming language

A reverse phase HPLC method is described for the determination of Ziprasidone HCl mono hydrate in bulk and pharmaceutical dosage forms. Chromatography was carried out on an ODS C18 column using a mixture of methanol and phosphate buffer (55:45v/v) as the mobile phase at a flow rate of 1mL/min. Detection was carried out at 314nm. The retension time of the drug was 4.522 min. The method produced linear responses in the concentration range of 0.5-30 μg /mL of Ziprasidone HCl mono hydrate.The method was found to be applicable for determination of the drug in capsules

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