Synthesis and Antifungal Activity of Azetidinone and Thiazolidinones Derivatives of 2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole | Zendy

K. H. Patel | Zendy; A. G. Mehta | Zendy

Open Access

Synthesis and Antifungal Activity of Azetidinone and Thiazolidinones Derivatives of 2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole

Author(s) -

K. H. Patel,

A. G. Mehta

Publication year - 2006

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2006/186294

Subject(s) - antifungal , chemistry , combinatorial chemistry , stereochemistry , microbiology and biotechnology , biology

amino-6-(2-naphthalenyl)thiazolo(3,2-d)thiadiazole (1) was prepared by treatment of KCNS and Br 2 on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) afford 2- azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of fungai.

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