Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact | Zendy

Marian Grade | Zendy; Heinz Becker | Zendy; Torsten Liersch | Zendy; Thomas Ried | Zendy; Β. Michael Ghadimi | Zendy

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Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact

Author(s) -

Marian Grade,

Heinz Becker,

Torsten Liersch,

Thomas Ried,

Β. Michael Ghadimi

Publication year - 2006

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2006/173815

Subject(s) - comparative genomic hybridization , colorectal cancer , fluorescence in situ hybridization , cytogenetics , molecular cytogenetics , karyotype , carcinogenesis , biology , cancer , cancer research , clinical significance , pathology , chromosome , medicine , genetics , gene

Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.

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