Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity | Zendy

Ketan Mistry | Zendy; K. R. Desai | Zendy

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Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity

Author(s) -

Ketan Mistry,

K. R. Desai

Publication year - 2005

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2005/690296

Subject(s) - quinazoline , chalcone , chemistry , pyrimidine , antibacterial activity , staphylococcus aureus , salmonella typhi , escherichia coli , catalysis , nitro , organic chemistry , medicinal chemistry , stereochemistry , bacteria , biochemistry , biology , alkyl , gene , genetics

Pyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted phenylchalconylhydrazinomethyl)-3-(p-methoxyphenyl)-quinazoline-4(3H)-one [3a-j] in the presence of catalytic amount of conc. HCl. And this series of chalcones have been synthesised by the reaction of 2-acetylhydrazinomethyl-3-(substitutedphenyl)-quinazoline-4(3H)-one [2] with different substituted aldehydes in presence of a 2% NaOH solution. These products have been characterized by means of elemental analysis, IR and NMR spectrul studies and tested for antibacterial activities against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi

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