p53, Bcl‐2 and C‐Myc Expressions in Colorectal Carcinoma Associated with Schistosomiasis in Egypt | Zendy

Khaled Zalata | Zendy; Wesam A. Nasif | Zendy; SiChun Ming | Zendy; Mahmoud Lotfy | Zendy; Nadia Nada | Zendy; Nabil Gad El-Hak | Zendy; Stephen H. Leech | Zendy

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p53, Bcl‐2 and C‐Myc Expressions in Colorectal Carcinoma Associated with Schistosomiasis in Egypt

Author(s) -

Khaled Zalata,

Wesam A. Nasif,

SiChun Ming,

Mahmoud Lotfy,

Nadia Nada,

Nabil Gad El-Hak,

Stephen H. Leech

Publication year - 2005

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2005/547010

Subject(s) - schistosomiasis , oncology , medicine , colorectal cancer , cancer research , carcinoma , biology , cancer , immunology , helminths

Oncogenes and tumor suppressor genes expression are well described in bladder cancer associated with schistosomiasis especially in Egypt. Scarce studies were directed to colorectal cancer (CRC) associated with Schistosoma mansoni (S. mansoni). Apoptosis (programmed cell death) and the genes regulating this process (e.g., Bcl-2) have recently become a focus of interest in the study of cancer development and progression. In the present study, we aimed to investigate the expression pattern of p53, Bcl-2 and C-Myc in CRC tissues obtained from Egyptian colorectal cancer patients divided in two different groups, one associated with Schistosoma mansoni (CRC-Sm) and the other without Schistosoma mansoni (CRC-NSm).

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