Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis | Zendy

Hans-Peter Hauber | Zendy; Céline Bergeron | Zendy; Anne Tsicopoulos | Zendy; B. Wallaert | Zendy; Ron Olivenstein | Zendy; Kenneth J. Holroyd | Zendy; Roy C. Levitt | Zendy; Qutayba Hamid | Zendy

Open Access

Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis

Author(s) -

Hans-Peter Hauber,

Céline Bergeron,

Anne Tsicopoulos,

B. Wallaert,

Ron Olivenstein,

Kenneth J. Holroyd,

Roy C. Levitt,

Qutayba Hamid

Publication year - 2005

Publication title -

canadian respiratory journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.675

H-Index - 53

eISSN - 1916-7245

pISSN - 1198-2241

DOI - 10.1155/2005/531432

Subject(s) - medicine , chronic bronchitis , bronchitis , chloride channel , calcium , biochemistry , chemistry

Interleukin (IL)-9 and its effect on enhancing the human calcium-activated chloride channel 1 (hCLCA1) expression have been shown to induce mucin production. Increased expression of hCLCA1 may, in turn, contribute to mucus overproduction in chronic obstructive pulmonary disease (COPD) with a chronic bronchitis (CB) phenotype.

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