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It is currently recommended that leukotriene modifiers (receptor antagonists and synthesis inhibitors) be withheld for a minimum of 24 h before direct bronchoprovocation testing, but there is little evidence to support this recommendation.

Effect of a Single Dose Montelukast Sodium on Methacholine Chloride PC20

Effect of a Single Dose Montelukast Sodium on Methacholine Chloride PC₂₀