Affinity studies of hypocrellin B and mono-cysteine substituted hypocrellin B with CT-DNA using spectroscopic methods | Zendy

Shaohua Wei | Zendy; Jiahong Zhou | Zendy; Yuying Feng | Zendy; Deyin Huang | Zendy; Xuesong Wang | Zendy; Baowen Zhang | Zendy; Jian Shen | Zendy

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Affinity studies of hypocrellin B and mono-cysteine substituted hypocrellin B with CT-DNA using spectroscopic methods

Author(s) -

Shaohua Wei,

Jiahong Zhou,

Yuying Feng,

Deyin Huang,

Xuesong Wang,

Baowen Zhang,

Jian Shen

Publication year - 2005

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2005/258617

Subject(s) - chemistry , circular dichroism , intercalation (chemistry) , dna , stacking , spectroscopy , fluorescence , fluorescence spectroscopy , crystallography , stereochemistry , biochemistry , organic chemistry , physics , quantum mechanics

The interaction of anticancer drug hypocrellin B (HB) and mono-cysteine substituted hypocrellin B (MCHB) with calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra showed that the HB and MCHB can intercalate into the base-stacking domain of the CT-DNA double helix. Further stud- ies based on fluorescence spectroscopy and circular dichroism (CD) spectroscopy also supported the intercalation mecha- nism.

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