Open AccessOne-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid
Author(s) -
TongShou Jin,
Ying Zhao,
Liu Libin,
TongShuang Li
Publication year - 2005
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2005/237237
Subject(s) - catalysis , chemistry , one pot synthesis , organic chemistry , combinatorial chemistry
An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time
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