Potential Capsule Switching from Serogroup Y to B: The Characterization of Three suchNeisseria meningitidisIsolates Causing Invasive Meningococcal Disease in Canada | Zendy

Raymond S. W. Tsang | Zendy; Dennis K. S. Law | Zendy; Shaun Tyler | Zendy; Gwen S Stephens | Zendy; Mark Bigham | Zendy; Wendell D. Zollinger | Zendy

Open Access

Potential Capsule Switching from Serogroup Y to B: The Characterization of Three suchNeisseria meningitidisIsolates Causing Invasive Meningococcal Disease in Canada

Author(s) -

Raymond S. W. Tsang,

Dennis K. S. Law,

Shaun Tyler,

Gwen S Stephens,

Mark Bigham,

Wendell D. Zollinger

Publication year - 2005

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 38

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/2005/216369

Subject(s) - neisseria meningitidis , multilocus sequence typing , microbiology and biotechnology , meningococcal disease , neisseriaceae , housekeeping gene , biology , virology , typing , neisseria , serotype , genotype , gene , genetics , bacteria , antibiotics , gene expression

Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.

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