Open AccessCervical Acid Phosphatase: A Biomarker of Cervical Dysplasia and a Potential Surrogate Endpoint for Colposcopy
Author(s) -
Olivera Marković,
Nenad Markovic
Publication year - 2004
Publication title -
disease markers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 66
eISSN - 1875-8630
pISSN - 0278-0240
DOI - 10.1155/2004/845798
Subject(s) - colposcopy , surrogate endpoint , dysplasia , medicine , biomarker , premalignant lesion , gynecology , cervical cancer , biology , pathology , genetics , cancer
In 2000, cervical acid phosphatase (CAP) has been recently described as a biomarker labeling abnormal squamous cells on Pap smears (USPTO #6,143,512). The enzyme activity is presented as a red, granular deposit on a modified Papanicolaou background. This unique property was utilized for development of MarkPap technology intended for cervical cancer screening.
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