The Matrix Metalloproteinase‐3 (MMP‐3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach | Zendy

Paul G. McGlinchey | Zendy; Mark S. Spence | Zendy; C. C. Patterson | Zendy; Adrian Allen | Zendy; Gillian Murphy | Zendy; Damian Fogarty | Zendy; Alun Evans | Zendy; Pascal McKeown | Zendy

Open Access

The Matrix Metalloproteinase‐3 (MMP‐3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

Author(s) -

Paul G. McGlinchey,

Mark S. Spence,

C. C. Patterson,

Adrian Allen,

Gillian Murphy,

Damian Fogarty,

Alun Evans,

Pascal McKeown

Publication year - 2004

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2004/715745

Subject(s) - ischaemic heart disease , transmission disequilibrium test , matrix metalloproteinase , genetics , biology , polymorphism (computer science) , linkage disequilibrium , allele , population , disease , matrix metalloproteinase 9 , gene , immunology , medicine , haplotype , environmental health

Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.

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