Preliminary study on the synthesis and high‒resolution NMR analysis of Naproxen and Ibuprofen esters | Zendy

Christopher K. Jankowski | Zendy; Gaëtan LeClair | Zendy; André Aumelas | Zendy; Mario González-de la Parra | Zendy; Manuel JiménezEstrada | Zendy; Veronica Tejada | Zendy; Ricardo ReyesChilpa | Zendy; Jacqueline M.R. Bélanger | Zendy; J. R. Jocelyn Paré | Zendy

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Preliminary study on the synthesis and high‒resolution NMR analysis of Naproxen and Ibuprofen esters

Author(s) -

Christopher K. Jankowski,

Gaëtan LeClair,

André Aumelas,

Mario González-de la Parra,

Manuel JiménezEstrada,

Veronica Tejada,

Ricardo ReyesChilpa,

Jacqueline M.R. Bélanger,

J. R. Jocelyn Paré

Publication year - 2004

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2004/610761

Subject(s) - naproxen , ibuprofen , chemistry , resolution (logic) , reagent , nmr spectra database , high resolution , carbon 13 nmr , proton nmr , organic chemistry , combinatorial chemistry , spectral line , medicine , computer science , pharmacology , physics , alternative medicine , remote sensing , pathology , astronomy , artificial intelligence , geology

Dedicated to J.M. Muchowski on his 65th birthday remembering the sabbatical at Syntex SA. Abstract. The synthesis and NMR analysis of several diastereoisomeric Naproxyl-Naproxenate, Naproxyl-Ibuprofenate and Ibuprofyl-Naproxenate esters are reported. The NMR high resolution spectra run in presence of the chiral shift reagents and variable temperature analysis were done to study the dynamic properties of these esters.

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