Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum | Zendy

Shunichi Takahata | Zendy; Hiroyuki Konomi | Zendy; Ann Schloithe | Zendy; James Toouli | Zendy; G. T. P. Saccone | Zendy

Open Access

Second-Generation Recombinant Hemoglobin Molecules Do Not Stimulate Sphincter of Oddi, Gallbladder, or Duodenal Motility in the Australian Brush-Tailed Possum

Author(s) -

Shunichi Takahata,

Hiroyuki Konomi,

Ann Schloithe,

James Toouli,

G. T. P. Saccone

Publication year - 2004

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2004/497284

Subject(s) - hemoglobin , sphincter of oddi , recombinant dna , medicine , motility , gallbladder , gastroenterology , chemistry , endocrinology , biology , biochemistry , gene , genetics

Several studies have investigated the effects of hemoglobin-based oxygen carriers on gastrointestinal motility. Diaspirin cross-linked hemoglobin reduces sphincter of Oddi trans-sphincteric flow and increases duodenal motility in the Australian brush-tailed possum, effects attributed to nitric oxide (NO) scavenging. Recently, second-generation recombinant hemoglobin molecules with reduced NO scavenging ability have been developed.

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