Near‐Infrared Fluorescence Optical Imaging and Tomography | Zendy

Michael Gurfinkel | Zendy; Ke Shi | Zendy; Xiaoxia Wen | Zendy; Chun Li | Zendy; Eva M. SevickMuraca | Zendy

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Near‐Infrared Fluorescence Optical Imaging and Tomography

Author(s) -

Michael Gurfinkel,

Ke Shi,

Xiaoxia Wen,

Chun Li,

Eva M. SevickMuraca

Publication year - 2004

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2004/474818

Subject(s) - fluorescence , molecular imaging , fluorescence lifetime imaging microscopy , preclinical research , optical imaging , medical physics , nanotechnology , materials science , medicine , optics , biology , physics , in vivo , microbiology and biotechnology

The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises selective and specific molecular targeting of diseased tissues. As an example of one area of the field, recent work focusing on pharmacokinetic analysis of fluorophores targeting the epidermal growth factor receptor (EGFR) is presented in a human breast cancer xenograft mouse model to demonstrate specificity of molecularly targeted contrast agents. Finally, a critical evaluation of the limitations and the opportunities for future translation of fluorescence-enhanced optical imaging of deep tissues is presented.

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