Surfactant — Where Are We in 2003? | Zendy

J. A. Lewis | Zendy

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Surfactant — Where Are We in 2003?

Author(s) -

J. A. Lewis

Publication year - 2004

Publication title -

canadian respiratory journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.675

H-Index - 53

eISSN - 1916-7245

pISSN - 1198-2241

DOI - 10.1155/2004/389625

Subject(s) - pulmonary surfactant , ards , medicine , intensive care medicine , acute respiratory distress , mechanical ventilation , surfactant therapy , respiratory distress , lung , anesthesia , pregnancy , physics , genetics , biology , thermodynamics , gestational age

Surfactant research has progressed over the past several years to the extent that exogenous surfactant administration in patients with the acute respiratory distress syndrome (ARDS) is now being evaluated. Unfortunately, clinical responses have been variable, and we now need to take a look at how surfactant is altered in this disease so that more effective treatment strategies can be developed. This review briefly discusses the biophysical and host defense properties of surfactant, the impact of mechanical ventilation (MV) on the endogenous surfactant system and the most recent clinical data involving exogenous surfactant administration in patients with ARDS. Discussions regarding future directions of surfactant research both in ARDS and diseases other than acute lung injury are included

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