Mycophenolic Acid Inhibits Replication of Type 2 Winnipeg, a Cerebrospinal Fluid-Derived Reovirus Isolate | Zendy

Laura Hermann | Zendy; Kevin M. Coombs | Zendy

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Mycophenolic Acid Inhibits Replication of Type 2 Winnipeg, a Cerebrospinal Fluid-Derived Reovirus Isolate

Author(s) -

Laura Hermann,

Kevin M. Coombs

Publication year - 2004

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 38

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/2004/387272

Subject(s) - mycophenolate , mycophenolic acid , cerebrospinal fluid , toxicity , virus , asymptomatic , virology , prodrug , biology , pharmacology , medicine , transplantation

The role of reoviruses in human disease is uncertain. Most identified cases are sporadic and asymptomatic or produce minor upper respiratory or gastrointestinal symptoms. In November 1997, a reovirus was isolated from the cerebrospinal fluid of a severe combined immune deficient infant in Winnipeg, Manitoba. RNA characterization and sequencing studies demonstrated this reovirus isolate to be unique. Thus, the virus was named Type 2 Winnipeg (T2W).

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