Differences between infrared spectra of normal and neoplastic human gastric cells | Zendy

Naoko Fujioka | Zendy; Yuji Morimoto | Zendy; Tsunenori Arai | Zendy; Kyoko Takeuchi | Zendy; Masahiko Yoshioka | Zendy; Makoto Kikuchi | Zendy

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Differences between infrared spectra of normal and neoplastic human gastric cells

Author(s) -

Naoko Fujioka,

Yuji Morimoto,

Tsunenori Arai,

Kyoko Takeuchi,

Masahiko Yoshioka,

Makoto Kikuchi

Publication year - 2004

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2004/347480

Subject(s) - infrared spectroscopy , infrared , absorbance , cancer , spectral line , chemistry , fourier transform , fourier transform infrared spectroscopy , normal group , nuclear magnetic resonance , pathology , medicine , optics , physics , chromatography , organic chemistry , quantum mechanics , astronomy

We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm −1 , 1120 cm −1 and 1080 cm −1 , compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm −1 and 3.8 cm −1 were seen at the peak absorbance in the bands around 1240 cm −1 and 1080 cm −1 , respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.

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