Asbestos and Probable Microscopic Polyangiitis | Zendy

George Philteos | Zendy; Kelly Coverett | Zendy; Rajni Chibbar | Zendy; Heather Ward | Zendy; Donald W. Cockcroft | Zendy

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Asbestos and Probable Microscopic Polyangiitis

Author(s) -

George Philteos,

Kelly Coverett,

Rajni Chibbar,

Heather Ward,

Donald W. Cockcroft

Publication year - 2004

Publication title -

canadian respiratory journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.675

H-Index - 53

eISSN - 1916-7245

pISSN - 1198-2241

DOI - 10.1155/2004/341942

Subject(s) - medicine , asbestosis , microscopic polyangiitis , anti neutrophil cytoplasmic antibody , pathology , autoantibody , serology , vasculitis , immunology , antibody , lung , disease

Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.

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