Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity | Zendy

S. R. Dhol | Zendy; P. M. Gami | Zendy; Ranjan C. Khunt | Zendy; A. R. PARIKH | Zendy

Open Access

Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

Author(s) -

S. R. Dhol,

P. M. Gami,

Ranjan C. Khunt,

A. R. PARIKH

Publication year - 2004

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2004/240397

Subject(s) - dithiocarbamate , chemistry , hydrazide , potassium hydroxide , antimicrobial , hydrazine (antidepressant) , hydrate , potassium , carbon disulfide , 1,2,4 triazole , organic chemistry , combinatorial chemistry , chromatography

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for their in vitroin vitro antimicrobial activity

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