Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues | Zendy

Martial Guillaud | Zendy; Dennis D. Cox | Zendy; Anaís Malpica | Zendy; Gregg Staerkel | Zendy; Jasenka Matisic | Zendy; Dirk Van Niekirk | Zendy; Karen AdlerStorthz | Zendy; Neal Poulin | Zendy; Michele Follen | Zendy; Calum MacAulay | Zendy

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Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues

Author(s) -

Martial Guillaud,

Dennis D. Cox,

Anaís Malpica,

Gregg Staerkel,

Jasenka Matisic,

Dirk Van Niekirk,

Karen AdlerStorthz,

Neal Poulin,

Michele Follen,

Calum MacAulay

Publication year - 2003

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2004/238769

Subject(s) - pathology , medicine

As part a Program Project to evaluate emerging optical technologies for cervical neoplasia, our group is performing quantitative histopathological analysis of biopsies from 1,800 patients. Several methodological issues have arisen with respect to this analysis: (1) Finding the most efficient way to compensate for staining intensity variation with out losing diagnostic information; (2) Assessing the inter- and intra-observer variability of the semi-interactive data collection; and (3) the use of non-overlapping cells from the intermediate layer only.

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