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Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotransmitter found in the brain and gut, may be related to the pathophysiology of IBS. It is reported that a 5-HT3 antagonist is effective only in female patients with diarrhea-predominant IBS.

canadian journal of gastroenterology

Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[<sup>11</sup>C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping

Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[11C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping

Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[¹¹C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping