Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[11C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping | Zendy

Akio Nakai | Zendy; Yoshikata Kumakura | Zendy; Michel Boivin | Zendy; Pedro RosaNeto | Zendy; Mirko Dikšić | Zendy; Doreen L. D'Souza | Zendy; Kathryn Kersey | Zendy

Open Access

Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[¹¹C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping

Author(s) -

Akio Nakai,

Yoshikata Kumakura,

Michel Boivin,

Pedro RosaNeto,

Mirko Dikšić,

Doreen L. D'Souza,

Kathryn Kersey

Publication year - 2003

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2003/572127

Subject(s) - statistical parametric mapping , positron emission tomography , irritable bowel syndrome , serotonin , tryptophan , nuclear medicine , medicine , physics , radiology , chemistry , magnetic resonance imaging , amino acid , biochemistry , receptor

Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotransmitter found in the brain and gut, may be related to the pathophysiology of IBS. It is reported that a 5-HT3 antagonist is effective only in female patients with diarrhea-predominant IBS.

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