Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy | Zendy

O Cartsburg | Zendy; C. Kallen | Zendy; Jost Hillenkamp | Zendy; R. Sundmacher | Zendy; Natalia Pomjanski | Zendy; Alfred Böcking | Zendy

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Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy

Author(s) -

O Cartsburg,

C. Kallen,

Jost Hillenkamp,

R. Sundmacher,

Natalia Pomjanski,

Alfred Böcking

Publication year - 2001

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2001/961735

Subject(s) - mitomycin c , pathology , feulgen stain , cytology , nuclear dna , cytometry , dna , cell , conjunctiva , aneuploidy , flow cytometry , biology , medicine , staining , microbiology and biotechnology , chromosome , biochemistry , genetics , gene , mitochondrial dna

Atypical cell changes often occur following treatment of premalignant or malignant conjunctival neoplasias with topical mitomycin C (MMC) and/or radiation. These reactive, non-neoplastic alterations of the conjunctival epithelium can be a differential diagnostic problem. Our aim was to investigate changes in the nuclear DNA-distribution of conjunctival epithelial cells after MMC- and radiation therapy by DNA-image-cytometry.

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