A Case of Chronic Pancreatic Insufficiency Due to Valproic Acid in a Child | Zendy

Mary Anne Cooper | Zendy; Aubrey Groll | Zendy

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A Case of Chronic Pancreatic Insufficiency Due to Valproic Acid in a Child

Author(s) -

Mary Anne Cooper,

Aubrey Groll

Publication year - 2001

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2001/687087

Subject(s) - valproic acid , pancreatitis , medicine , exocrine pancreatic insufficiency , steatorrhea , gastroenterology , abdominal pain , etiology , pancreas , acute pancreatitis , weight loss , pediatrics , epilepsy , psychiatry , obesity

A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis. The association with valproic acid was not recognized, and the child continued to take the drug. The patient eventually developed steatorrhea and weight loss that improved with pancreatic enzyme replacement. Radiological evaluation showed an atrophic pancreas. Without evidence of other etiological factors, valproic acid by itself appeared to be the cause of chronic pancreatitis with exocrine pancreatic insufficiency in this patient.

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